Illustration of the signs of ageing in skin, dulling of the epidermis, brown spots, skin slackening and wrinkles. From top to bottom: -illustrates the dulling of the epidermis, the skin is dry and cutaneous microrelief is irregular, causing the skin to become permeable to pollutants and dehydration. Superficial microcirculation is less good; skin cells become less oxygenated. -illustrates spots. If they are brown it is due to melanin deposits, when red it is due to superficial microcirculation vessels, which are dilated. -illustrates the loss of firmness due to diminished activity of the fibroblasts (blue). Fibroblasts are responsible for skin’s elasticity, producing elastin and collagen -illustrates wrinkles due to the deterioration of collagen (white vertical) and elastin (pink horizontal) fibers.